The Insulin-Only Bionic Pancreas Improves Glycemic Control in Non-Hispanic White and Minority Adults and Children With Type 1 Diabetes

Luz E. Castellanos,Steven J. Russell,Edward R. Damiano,Roy W. Beck,Viral N. Shah,Ryan Bailey,Peter Calhoun,Keisha Bird,Nelly Mauras,R. Paul Wadwa, Greg Forlenza,Robert Slover,Laurel Messer,Erin Cobry,Viral Shah,Sarit Polsky,Emily Jost,Cari Berget, Lindsey Towers, Samantha Lange, Estella Escobar, Christie Beatson, Sonya Walker, Angela Karami, Emily Boranian,Bruce Buckingham,Rayhan Lal,Laya Ekhlaspour,Michael S. Hughes,Marina Basina,Liana Hsu,Betul Hatipoglu,Keren Zhou, Leann Olansky, Ana Surckla, Laura Lomeli,Diana Isaacs,Shannon Knapp, Andrea Debs, Tracy Tomaro,Julia Blanchette,Steven Russell,Jordan Sherwood,Luz Castellanos,Mallory Hillard,Marwa Tuffaha,Melissa Putman, Mollie Sands,Courtney Balliro,Evelyn Greaux,Barbara Steiner, Sarah Gaston, Rachel Bartholomew, Kim Martin,Mark Daniels,Amrit Bhangoo,Nikta Forghani,Himala Kashmiri, Francoise Sutton, Heather Speer, Marissa Erickson, Samantha Thompson, Allyson McDaniel,Philip Raskin, Suzanne Strowig, Lin Jordan,Perrin White,Abha Choudhary, Jimmy Penn, Michael Henson, Yasmin Molina, Chantal Nwosu, Vanda Kumar, Angie Burris, Kim Jernigan, Brittany Mann,Jane Lynch,Rabab Jafri,Maria Rayas, Elia Escaname, Catherine Kerr, Ruby Favela-Prezas, Sara Olivarri,Jeremy Pettus,Schafer Boeder, Todd May, Adrienne Armstrong, Erin Giovanetti,Irl Hirsch,Subbulaxmi Trikudanathan, Nancy Sanborn, Xenia Averkiou,Robin Goland,Kristen Williams, Natasha Leibel, Jamie Hyatt, Sarah Pollak, Elizabeth Robinson, Emily Casciano, Analia Alvarez, Eleanor Zagoren, Jaclynn Johnson, Silpa Sharma, John Buse, M. Sue Kirkman, Kate Bergamo, Klara Klein, Jean Dostou, Sriram Machineni, Laura Young, Jamie Diner, Alex Kass, Virginia Purrington, Rachel Fraser, Julie Uehling, Davida Kruger, Arti Bhan, J. Kimberly Jones, Terra Cushman, Heather Hunter, Natalie Corker, Shereen Mukhashen,Nelly Mauras, Matthew Benson,Keisha Bird, Kimberly Englert, Joe Permuy, Kimberly Ponthieux, Albina Tarko, Andrew Muir, J. Nina Ham, Kristina Cossen, Eric Felner, Amber Antich, Wanda Sanchez, Mone Anzai, Kathryn Lucas, Catherine Simpson, Janet McGill, Maamoun Salam, Julie Silverstein, Samantha Adamson, Andrea Cedeno, Mary Jane Clifton, Toni Schweiger, Traci Bell, Fran Cogen, Seema Meighan, Andrew Dauber, Meryll Castro, Tara McCarthy, Kimberly Boucher, Helen Jenkins, Jill Weissberg-Benchell, Katrina Ruedy,Roy Beck, Sarah Borgman, Sydnee Bradshaw, Paige Miller, Zoey Li,Peter Calhoun, Martin Marek, Rosa Pritchard, Elizaveta Dolzhenko,Edward R. Damiano, Firas H. El-Khatib, Deanna Gabrielson, Julie Idzorek, Anne Elstrom-Park, Guillermo Arreaza-Rubin, Thomas Eggerman, Neal Green, Steven H. Belle, Jessica Castle, Jennifer Green, Laurent Legault, Steven M. Willi, Carol Wysham,

Diabetes Care（2023）

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摘要

OBJECTIVE We evaluated the performance of the iLet bionic pancreas (BP) in non-Hispanic Whites (“Whites”) and in Blacks, Hispanics, and others (“Minorities”). RESEARCH DESIGN AND METHODS A multicenter, randomized controlled trial evaluated glycemic management with the BP versus standard of care (SC) in 161 adult and 165 pediatric participants with type 1 diabetes over 13 weeks. RESULTS In Whites (n = 240), the mean baseline-adjusted difference in 13-week HbA1c between the BP and SC groups was −0.45% (95% CI −0.61 to −0.29 [−4.9 mmol/mol; −6.6 to −3.1]; P < 0.001), while this difference among Minorities (n = 84) was −0.53% (−0.83 to −0.24 [−6.0 mmol/mol; −9.2 to −2.8]; P < 0.001). In Whites, the mean baseline-adjusted difference in time in range between the BP and SC groups was 10% (95% CI 7–12; P < 0.001) and in Minorities was 14% (10–18; P < 0.001). CONCLUSIONS The BP improves glycemic control in both Whites and Minorities and offers promise in decreasing health care disparities.

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