Figure S4 from miR-139-5p Modulates Radiotherapy Resistance in Breast Cancer by Repressing Multiple Gene Networks of DNA Repair and ROS Defense

RT + miR-139-5p mimic-treated tumours had significantly decreased Ki-67-positive cells, and significantly increased phospho-H2AX- and caspase-3-positive cells compared to control mimic-treated tumours (A-C). phospho-H2AX immunostaining was confined to the tumour field that received the radiation; the kidneys and liver, non-target organs that were not within the radiation field but which accumulated miRNA mimic did not have detectable phospho-H2AX expression (D-E).