Supplementary Figures 1-10 from Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

PDF file - 4.5MB, Figure S1. HMGB1 inhibitors hinder asbestos-induced HM transformation. Figure S2. Expressions of the HMGB1 receptors TLR2 and TLR4 are variable in MM cells. Figure S3. HMGB1 is a chemotactic and mitogenic factor in MM cells. Figure S4. Secreted HMGB1 is an autocrine chemotactic factor in MM cells. Figure S5. HMGB1 inhibition has no effect on the survival and migration of MM cells that are low HMGB1 producers (PPM-Mill). Figure S6. HMGB1 inhibition does not induce cell death in HM. Figure S7. Inhibition of HMGB1 induces apoptosis in MM cells "addicted" to HMGB1. Figure S8. HMGB1 supports the invasive phenotype in MM cells. Figure S9. Gene expression analysis of REN cells treated with HMGB1.