Supplemental methods, references, figure legends and figures S1-S7 from Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies

Supplemental methods, references, figure legends and figures S1-S7. Figure S1. HDAC inhibition causes decreased Bcl-2 and Bcl-xL protein expression and cell death in multiple hematopoietic malignancies. Figure S2. HDAC inhibition increases global histone acetylation, but no change in transcription at BCL-2 and BCL-XL loci. Figure S3. miR-15 family targets Bcl-2 to induce apoptosis. Figure S4. miR-15 family and let-7a increase in lymphomas upon HDAC inhibition and induce apoptosis. Figure S5. Myc upregulates members of the miR-15 family and let-7a in untransformed cells. Figure S6. MYC ChIPs to the promoters of the miR-15 family and let-7a and HDACi induces miR-15 family and let-7a expression. Figure S7. Myc:Miz-1 interactions do not mediate Bcl-2 and Bcl-XL repression.