Supplementary Data from Collagen Prolyl Hydroxylases Are Essential for Breast Cancer Metastasis

Supplementary Data PDF file 764K, Supplementary Figure S1, HIF-1 dependent P4HA1 and P4HA2 induction Supplementary Figure S2, P4HA1 and P4HA2 knockdown inhibits breast cancer growth and metastasis Supplementary Figure S3, Collagen hydroxylase knockdown decreases collagen deposition in vivo Supplementary Figure S4, P4HA1 and P4HA2 knockdown inhibits growth and metastasis of MDA-MB-435 cells Supplementary Figure S5, Picrosirius red staining of mouse lungs Supplementary Figure S6, P4HA re-expression in HIF-deficient cells rescues collagen deposition and metastasis Supplementary Figure S7, DHB treatment of MDA-MB-231 Cells Supplementary Table S1, Real-time qPCR primers. Supplemental Table S2, Comparison of human P4HA1 mRNA versus mouse P4HA1 mRNA expression in tumors. Supplemental Table S3, Correlation of P4HA1 and P4HA2 mRNA expression with receptor status