Supplementary Figures S1-S8 from Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma

Supplementary Figures S1-S8: Supplementary Figure S1: Data sets comparing gene expression of OCCC to other histological subtypes or normal ovary demonstrate increased levels of Sod2 in OCCC. Supplementary Figure S2: Representative Sod2 in-gel activity blots demonstrating Sod2 knock-down in ES-2 and TOV-21-G cells with two different siRNAs. Supplementary Figure S3: Effects of Sod2 shRNA-mediated knockdown on ES-2 cells proliferation and clonogenicity Supplementary Figure S4: Effects of Sod2 knock-down on apoptosis. Supplementary Figure S5: Effects of Sod2 knock-down on OCR and ECAR. Supplementary Figure S6: Effects of Sod2 shRNA-mediated knock down on migration and Akt phosphorylation. Supplementary Figure S7: Exogenously applied bovine catalase is taken up intracellularly and retained for up to 72hrs by ES-2 cells Supplementary Figure S8: Catalase expression results in decreased Akt phosphorylation in ES-2 cells.