Supplementary Tables 1 through 5 from Variation in Mutation Spectrum Partly Explains Regional Differences in the Breast Cancer Risk of Female <i>BRCA</i> Mutation Carriers in the Netherlands

Supplementary Table 1. Clinical characteristics of BRCA1/2 carriers including index cases in the Northern Netherlands (study population) and in the rest of the Netherlands (reference population). Supplementary Table 2. Overview of number of carriers (excluding index cases) at risk at each age-decade and number of breast cancer event for each age-decade. Supplementary Table 3. Cumulative incidence of breast cancer in BRCA1/2 carriers, excluding index cases, in the study population (Northern Netherlands) and reference population (rest of the Netherlands). Estimation of risks weighted to an equal contribution from the different birth cohorts in each population. Supplementary Table 4. Relative risks (hazard ratios (95% confidence interval)) of breast cancer for mutation spectrum, excluding index cases. Supplementary Table 5. Regional differences in the breast cancer risk of BRCA1/2 carriers including index cases (adjusted for birth year) in the Netherlands: the study population (Northern Netherlands) compared to the reference population (the rest of the Netherlands.)