Supplementary Figure S1-S8 from CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs

Figure S1 shows elevated expression of circPDIA4 in gastric cancer tissues and impacts on viability of gastric cancer cells. Figure S2 shows that circPDIA4 enhanced invasive activities of gastric cancer cells. Figure S3 shows that circPDIA4 enhanced invasive activities of gastric cancer cells. Figure S4 shows that transcriptional factor SP1 plays an important role in up-regulating QKI expression in gastric cancer. Figure S5 shows that ERK1/2 interacts with circPDIA4 and phosphorylated ERK1/2 protein co-localizes with DUSP6 in gastric cancer. Figure S6 shows impacts of circPDIA4 on effects of different ERK inhibitors in gastric cancer. Figure S7 shows that silenced circPDIA4 promoted the suppression of cell viability induced by silencing of MAPK1 expression. Figure S8 shows that circPDIA4 facilitated oncogenic circRNAs formation depending on the RNA helicase DHX9 in gastric cancer.