Supplementary Data from Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1

Supplementary Tables - Supplementary Tables S1-3. Table S1. List of quantitative RT-PCR primers used in this study; Table S2. List of ChIP-qPCR primers used in this study; Supplementary Table S3. Distribution of H3K9me3 ChIP-seq peaks in various types of human cancer cells. Supplementary Figures - Supplementary Figures S1-7. Supplementary Figure S1. Enrichment profile plots of the KDM4B-dependent H3K9me3 peaks overlapped SINE, LTR, genebody and intergenic in three cell types; Supplementary Figure S2. The LINE-1 phylogenetic tree and the evaluation of H3K9me3 signal in selected evolutionarily young LINE-1 element; Supplementary Figure S3. Effect of KDM4 proteins on LINE-1 expression; Supplementary Figure S4. Schematic illustration of retrotransposition cassette assay; Supplementary Figure S5. The ORF1p, global H3K9me3 and DNA damage level were detected in various breast cell lines; Supplementary Figure S6. The retrotransposition cassette assay in breast cancer cells and normal breast epithelial cells; Supplementary Figure S7. ORF2 expression is sufficient to induce the DNA damage.