Supplementary Figures S1-S8 from Chronic Inflammation Induces a Novel Epigenetic Program That Is Conserved in Intestinal Adenomas and in Colorectal Cancer

Supplementary Figures S1-S8. Intestinal inflammation and tumor formation in the AOM/DSS model (S1); Methylome analysis of the mouse AOM/DSS model (S2); Global hypermethylation of intestinal DMVs in the AOM/DSS model (S3); Transcriptome analysis of the mouse AOM/DSS model (S4); Representative 454 bisulfite sequencing results for the Adh1 DMV in wild-type and adenoma-derived epithelium (S5); Inhibition of alcohol dehydrogenase enhances the growth of established organoids (S6); VDR as a representative example for a human gene associated with a DMV-like structure (S7); Definition of a minimum subset of genes for sample classification (S8).