Supplementary Figures S1-S5 from Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases

Dynamic light scattering analysis of nAb-PTX dispersed in water. The mean diameter of the aggregates is 12.4nm ; Gross appearance of breast (4T1) and lung (3LL) liver metastasis following various therapies ; Histological evaluation (H&E) consequently revealed that the tumor diameters at microscopic level in breast (4T1 cells) or lung (3LL cells) liver metastases were significantly smaller in the mice treated with MSV-nAb-PTX as compared to other therapy groups ; Dose response curves of viability of 4T1, 3LL cells, and abdominal macrophages treated with nAb-PTX and MSV-nAb-PTX as determined by MTT and WST-1 assay ; MSV biodistribution in 4T1 primary tumor and liver in the mice pre-treated with/without clodronate liposomes was evaluated by ICP-AES analysis .