Supplementary Figures S1-S5 from Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis

Supplementary Figures S1-S5. Identification of TMPRSS2 as a mediator of androgen-induced prostate cancer cell invasion (S1); TMPRSS2 induced matriptase activation in prostate cancer cells (S2); TMPRSS2 promoted matriptase activation and the shedding of matriptase and HAI-1 in PCa cells (S3); Examination of the role of TMPRSS2 in the body weights of xenograft mice, the levels of total matriptase, Ki67 and laminin β1 in xenograft tumor tissues (S4); Higher levels of TMPRSS2 expression correlate with higher levels of matriptase activation in human PCa pathological specimens (S5).