Supplementary figures S7, S8, S9, S10, S11, S12 from Enhancer Remodeling and MicroRNA Alterations Are Associated with Acquired Resistance to ALK Inhibitors

Supplementary Figure S7. Supplementary Figure S8. Transfection efficiency of miR-34a and miR-449a mimics and inhibitors in cell lines, related to Fig. 3. Supplementary Figure S9. The effects of miR-34a and miR-449a inhibitors on the viability of parental H3122 cells. Supplementary Figure S10. Genes with H3K27ac gain or loss in their promoters induced by the panobinostat treatment, related to Fig. 4. Supplementary Figure S11. H3122 and H3122-LR cells treated with ceritinib alone (1 Ã,µM), panobinostat alone (100 nM), or the combination, related to Fig. 5. Supplementary Figure S12.