Supplementary Materials and Methods, Figures 1 - 11, Tables 1 - 4 from Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells

Supplementary Figure 1. Metabolic alteration in LSD1-inhibited cancer cells. Supplementary Figure 2. Overall view of the metabolomic analysis in LSD1-KD HepG2 cells. Supplementary Figure 3. GSEA results of the microarray experiment in LSD1-KD HepG2 cells. Supplementary Figure 4. Effect of LSD1-KD on energy metabolism in Huh-7, human hepatocellular carcinoma cells. Supplementary Figure 5. Effect of LSD1-KD on the expression of the glucose transporter GLUT1. Supplementary Figure 6. Overexpression of LSD1 in HepG2 cells. Supplementary Figure 7. Effect of LSD1-KD on the expression of metabolic genes in breast cancer cells. Supplementary Figure 8. Distinct expression of LSD1 in hepatocellular carcinoma and normal hepatic cells. Supplementary Figure 9. LSD1 regulates glycolytic genes through the HIF-1a-mediated pathway. Supplementary Figure 10. LSD1 physically interact with HDACs but not with HIF-1a/HIF-1B in HepG2 cells. Supplementary Figure 11. Effect of LSD1 inhibition in mouse xenograft model. Supplementary Table 1. siRNAs target sequences. Supplementary Table 2. Concentrations of the metabolites indicated in Figure 1E. Supplementary Table 3. Full descriptions of the gene abbreviations used in this study. Supplementary Table 4. Primers used in the study.