Supplementary Figures S1-S11 from Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma

Mechanism of ON123300 induced MM cell death (S1); PD0332991 less significantly induces apoptosis in MM1.S cell and does not induce apotosis in NCI-H929 cells (S2); PD0332991 induces cell cycle arrest in MM1.S cells and not in NCI-H929 cells (S3); ON123300 induces cell cycle arrest in MM cells (S4); Molecular effects of treatment with PD0222991 in MM cell lines (S5); Effects of ARK5 depletion on MM cell viability by siRNA transfected MM1.S and NCI-H929 cells (S6); Anti-MM activity of SRT1720 (S7); Effect of ARK5 silencing by siRNA induces apoptosis in MM (S8); Effect of ARK5 silencing by siRNA enhances G1/S cell cycle arrest in MM (S9); ON123300 overcomes bone marrow stromal cell (BMSC) induced growth of MM Cells (S10); In vivo MM xenograft ON123300 inhibition (S11).