Supplementary Information from Integrative Modeling Identifies Key Determinants of Inhibitor Sensitivity in Breast Cancer Cell Lines

This document contains Supplementary Materials & Methods including a mathematical specification of the model, as well as Supplementary Note 1 (Inferred signaling estimates agree with on-treatment phosphorylation measurements), Supplementary Note 2 (A simplified model can describe the response to seven drugs simultaneously), Supplementary Note 3 (Inclusion of feedback signaling from MTORC1 to PI3K does not improve the fit for drug response to AZD8055 and lapatinib), Supplementary Tables 1 (cell line panel), 9-10 (literature references for model nodes and interactions) and 11-12 (prior distributions), and Supplementary Figure 1-19.