Supplementary Figures 1 - 7 from Novel Modeling of Cancer Cell Signaling Pathways Enables Systematic Drug Repositioning for Distinct Breast Cancer Metastases

PDF file - 1060K, CCSB derived signaling networks for distinct breast cancer metastases (S1); Chemical structures of the candidate repositioned drugs and their parameters for the "Rule of Five." (S2); Western Immunoblot analysis of RET, FYN and the down-stream pathway proteins in indicated cell lines (S3); Relationship between the brain metastasis core signaling network and ER, PR, HER2 status in different breast tumor cohorts (S4); Evaluation of p-FYN and p-RET activation and tumor loci surrounding edema and vessels in the brain metastatis mouse models (S5); Pharmacokinetic study of Sunitinib and Dasatinib accumulated in brain of the xenograft models (S6); The three-dimensional cubes for the best subtrees in the survival analysis (S7).