Total Stepwise Solid-Phase Synthesis of Oligonucleotide-Peptide Conjugates Using Side-Chain Boc/tBu Protection Group

Changlin Tian,Tao Wang,Xiuxiu Cao, Yong Zheng,Chenchen Chen, Li Zhou,Demeng Sun,Gemin Fang

Chemical Communications（2023）

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摘要

A practical strategy for total stepwise solid-phase synthesis of peptide-oligonucleotide conjugates was developed. In this strategy, Boc/tBu protection group is utilized for the side chains of Trp, His, Arg, Asp,...

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