Data Supplement from Body Size, Physical Activity, Early-Life Energy Restriction, and Associations with Methylated Insulin-like Growth Factor–Binding Protein Genes in Colorectal Cancer

Supplemental Table 1. Primer sequences used to analyze CpG island promoter hypermethylation of IGFBP2, IGFBP3, and IGFBP7 in colorectal tumors. Supplemental Table 2. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for colorectal cancer by extent of IGFBP methylation in relation to body size, physical activity, and early life energy restriction in men in the Netherlands Cohort Study (1989-1993). Supplemental Table 3. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for colorectal cancer by extent of IGFBP methylation in relation to body size, physical activity, and early life energy restriction in women in the Netherlands Cohort Study (1989-1993). Supplemental Table 4. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for colorectal cancer by IGFBP2, IGFBP3, and IGFBP7 methylation status in relation to body size, physical activity, and early life energy restriction in the Netherlands Cohort Study (1989-1993).