Supplementary Figures from Ovarian Cancers Harboring Inactivating Mutations in <i>CDK12</i> Display a Distinct Genomic Instability Pattern Characterized by Large Tandem Duplications
crossref(2023)
22 Supplementary Figures: CDK12 mutations detected in TCGA (S1-2) and in-house (S3) tumors; TDs in CDK12-mutated tumors (S4); Microhomology at the breakpoints and the size of TDs in CDK12-mutated tumors (S5); Copy number alteration profiles of eaPEO14 and PEO14 samples (S6); CDK12 mutation in PD3722a sample (S7); TDs in 25 TCGA cases with WGS (S8); Tumors with frequent TDs in the TCGA cohorts (S9); TD-plus phenotype in breast and prostate cancers (S10); GC content and mutation rate in TDs (S11); Recurrence analysis of TDs (S12); Replication time and CTCF binding sites at TDs (S13). TDs and gene loci (S14); Genomic signatures of HRD and CDK12 TD-plus phenotype (S15); Copy number profiles in tumors with CDK12 TD-plus phenotype (S16); CDK12 mutated tumors and mesenchymal subtype (S17); Molecular features of tumors with CDK12 TD plus phenotype (S18); Genes correlated to CDK12 (S19); Expression of ATM and CSTF3 and RPRD1A in a CDK12 context (S20); Alteration profiles of SKOV3 cell line (S21); The size of microhomology at the breakpoint junctions (S22).
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