Supplementary Data from MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

The Supplementary Materials and Methods describes the organic chemical routes employed to synthesize the PROTACs A1874, A1875 and A743. The procedures are explained in detail and the testing done to validate the chemical structures and purity are disclosed.