Supplementary Tables 1 through 3, Supplementary Figures 1 through 10 from Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Table S1: The redox status of the cell correlates with sensitivity to MTH1 inhibition. Table S2: Data collection and refinement statistics. Table S3: Kinetic parameters of zfMTH1. Table S4: Primer sequences. Figure S1: BSO treatment sensitizes U2OS and U343 cells against MTH1 inhibition. Figure S2: pre-treatment with PEG-catalase protects cancer cells against MTH1 inhibition. Figure S3: Alignment of human and zebrafish MTH1. Figure S4: Purification of zebrafish MTH1. Figure S5: Electron density for TH588 in the structure of Zebrafish MTH1. Figure S6: knock-down of VHL in HAEB cells sensitizes to the MTH1 inhibitor TH588. Figure S7: TH588 is well tolerated of zebrafish embryos. Figure S8: Expression of MTH1 in VHL knock-out background. Figure S9: Experimental setup for DMOG exposure of zebrafish embryos. Figure S10: ZebROS exposed to reducing and oxidizing agent.