Supplementary Figure S3 from Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance

Class I HDACs protect melanoma cells in vivo. (A) Effect of HDAC inhibition on growth inhibition of A375 melanoma xenografts following TMZ. Tumor volume is shown as a function of time. See materials and methods for detailed treatment conditions. Data are represented as mean {plus minus} SEM. *p<0.05. (B) Effect of treatment on the weight of the mice carrying A375 melanoma xenografts as a function of time.