Supplemental Figures from Demethylation-Induced Overexpression of Shc3 Drives c-Raf–Independent Activation of MEK/ERK in HCC

This file contains all Supplemental figures and Legends for Supplemental figures. Figure S1: Increased Shc3 expression is associated with HCC metastasis. Figure S2: Shc3 interacts with MVP. Figure S3: Shc3/MVP complex activates the MEK and ERK pathway. Figure S4: Shc3 promotes HCC proliferation and invasion in vitro. Figure S5: Shc3 induces EMT by interacting with MVP. Figure S6: MVP rescues Shc3-induced proliferation and migration. Figure S7: DNA methylation affects Shc3 transcription. Figure S8: Shc3 promotes tumor growth and intrahepatic metastasis in vivo. Figure S9: Shc3 promotes tumor growth and intrahepatic metastasis through MVP in vivo.