Supplemental Figure 8 from Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity

The effect of polyamine depletion with herbacetin on cancer cell doubling time. Colon cancer cells were stably transfected with shControl, shODC, Mock or SAT1. (A-B) The effect of herbacetin on HCT116 or HT29 colon cancer cell doubling time was assessed in shControl and shODC cells. (C-D) The effect of herbacetin on HCT116 or HT29 colon cancer cell doubling time was assessed in Mock and SAT1 cells. All data are represented as mean values {plus minus} S.D. of triplicate values from 3 independent experiments. The asterisk (*) indicates a significant effect (p < 0.05) of herbacetin compared to untreated controls.