Relationship between serum endothelin-1 and in-stent restenosis following vertebral artery stenting

Abstract Objective To investigate the correlation of serum endothelin-1(ET-1)and instent restenosis in vertebral artery stenting. Methods A total of 68 patient undergoing re-examination of vertebral artery stenting in the Department of Cerebrovascular Disease, Hangzhou Third People's Hospital from from April 2019 to October 2022 were recruited in this study.According to the existent of vertebral artery stenting or not,the patients were divided into restenosis group (n=19) and non-restensis group (n=49).The general clinical data and ET-1 level were compared between the 2 groups.Logistic regression analysis was used to explore the relationship between ET-1 level and risk for in-stent restenosis.ROC curve was drawn to test the diagnostic value of serum ET-1 level for instent restenosis. Results Compared with the non-restenosis group, the levels of Low Density Lipoprotein (LDL), TG, and ET-1 in the restenosis group were significantly increased (p<0.05) The Pearson correlation analysis showed that when comparing the relevant indices between the two groups, ET-1, LDL, TG, stent diameter, and stent length were positively correlated with ISR (p<0.05). The multivariate logistic regression analysis showed that ET-1, stent length, and LDL were independently associated with ISR(OR=1.502，95%CI: 0.042~0.212,p=0.000; OR=1.899,95%CI: 1.116~2.237,p=0.000;OR=1.899,95%CI: 1.228~3.337,p=0.001;）the area under the curve of serum ET-1 in the diagnosis of vertebral artery ISR was 0.938, the best diagnostic cut-off value was 11.94 ng/L, the sensitivity was 89.5%, and the specificity was 85.7%. Conclusion ET-1 level is independently associated with in-instent restenosis.