Supplementary Figures from Inhibition of ATM Induces Hypersensitivity to Proton Irradiation by Upregulating Toxic End Joining

Suppl. Figures 1-5. Supplemental Figure 1. Increased engagement of resection machinery and delayed repair following proton Bragg peak-induced DNA damage. Supplemental Figure 2. DNApk inhibition does not enhance the relative efficacy of proton Bragg peak irradiation. Supplemental Figure 3. Proton Bragg peak irradiation does not enhance the relative efficacy of proton Bragg peak irradiation on XRCC4 and LIG4 deficient tumor cells. Supplemental Figure 4. LIG4 knockdown attenuates ATM inhibitor-induced RBE enhancement of Bragg peak irradiation. Supplemental Figure 5. Loss of BRCA2 and RAD51 enhances the RBE of proton Bragg peak irradiation.