病原高通量测序在中枢神经系统感染患者中的应用效果
Chinese Journal of Medical Device(2023)
Abstract
目的 探究病原高通量测序与传统检验方法在中枢神经系统(CNS)感染患者中的应用效果.方法 选取2020年10月至2022年9月医院收治的80例CNS感染患者资料进行回顾性分析,根据病原微生物检测方法分为对照组和试验组,各40例.对照组采用形态学检查、生化检查、培养分离、免疫学等常规病原微生物检查,试验组采用病原高通量测序.观察并记录两组病原微生物检出率、症状改善天数(意识障碍、头痛、呕吐、发热等)、住院总天数及治愈率.结果 利用高通量测序检测出阳性结果28例,阳性检出率为70.00%,传统方法检测出阳性结果7例,阳性检出率为17.50%,试验组高于对照组,差异有统计学意义(P<0.05);试验组症状改善天数和住院总天数明显短于对照组,差异有统计学意义(P<0.05);试验组治愈率高于对照组,差异有统计学意义(P<0.05).结论 病原高通量测序在CNS感染患者检测中的阳性检出率较高,有利于临床医师及时干预治疗,提高治愈率,缩短症状改善时间及住院时间.
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