In utero bisphenol A exposure disturbs germ cell cyst breakdown through the PI3k/Akt signaling pathway and BDNF expression

Chunming Li,Tongyun Qi,Linjuan Ma,Yi Bing Lan,Jie Luo,Ketan Chu,Yizhou Huang,Fei Ruan,Jianhong Zhou

Ecotoxicology and Environmental Safety（2023）

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摘要

•BPA altered the expression of the key steroid hormone synthesis-related genes P450scc and aromatase.•Environmentally relevant levels of BPA in utero exposure can disrupt the germ cell nests breakdown.•The mechanism of this inhibition seems to be involved in PI3k/Akt signaling pathway and BDNF expression.

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关键词

Bisphenol A (BPA),Primordial follicle pool,PI3K/Akt,Steroidogenic enzyme,Brain-derived neurotrophic factor,Ovarian function

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