Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to

30 The mutational changes occurring in the regulatory genes responsible for the maintenance of 31 optimal cell growth and proliferation gradually lead to cancer progression and metastasis. 32 Furthermore, patients with the same cancer types often respond differently to different cancer 33 therapies, indicating the need for a patient-specific treatment regimen for the disease. Precision 34 oncology is the new field of cancer research that relies on genetic profiling of individual tumors 35 to identify targetable alterations for custom-tailored personalized treatment of the disease. It is to 36 rely upon the genomic study of cancer cells to get a clear picture of the prognosis and pathways 37 involved in disease progression and to look for the means to selectively target them for a cure. 38 This article intends to briefly explain the foundations and frontiers of precision oncology in the 39 context of technological advances being made in this direction to assess its scope and importance 40 in the realization of a proper cure for cancer. 41 42