Figure S6 from <i>LINC00261</i> Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response

Figure S6. TCGA LUAD methylation at the LINC00261 locus. A. Individual CpGs are denoted by their Illumina 450K designation. Scale = 0 (no methylation) to 1 (complete methylation). Hg19-based coordinates for each probe are listed below the cg ascension number. Distance from the LINC00261 Transcription Start Site (TSS) is also shown. "+" is downstream of TSS (within the gene), "-" is upstream of TSS. B. RNA expression levels of DNMT enzymes in normal human alveolar epithelial cells (AEC) and available 16 LUAD cancer cell lines (LUAD). Dashed line denotes RPKM cutoff of 3, the commonly accepted cutoff for baseline expression. ** = p value 0.0076, unpaired T Test. N=3 for AEC, 16 for LUAD.