Supplementary Figures from A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence

Supplementary Figure 1: MiR-27b-3p and miR-455-3p promote cellular quiescence in B16 mouse melanoma cells. Supplementary Figure 2: miR-27b-3p and miR-455-3p are conserved in various mammal species. Supplementary Figure 3: MiR-27b-3p and miR-455-3p promote p27 stabilization through downregulating Skp2 and promoting p27 phosphorylation at Thr187, respectively. Supplementary Figure 4: MiR-27b-3p and miR-455-3p target Cks1 and CAC1, respectively. Supplementary Figure 5: The genomic locus of miR-27b-3p and miR-455-3p. Supplementary Figure 6: miR-27b-3p and miR-455-3p are p53-responsive miRNAs. Supplementary Figure 7: p53 drives cellular quiescence through miRNA-27b-3p and miRNA-455-3p.