Supplementary Figures 1 through 7, Supplementary Tables 1 and 3, and Supplementary Materials and Methods from Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression

Figure S1. Generation and characterization of orthotopic SCC lineages. Figure S2. Analysis of CSC frequency and EMT induction during SCC progression. Figure S3. Characterization of primary culture cells derived of WD-SCCs and PD/S-SCCs. Figure S4. Activation of autocrine PDGFRα signaling in PD/S-SCCs. Figure S5. In vitro and in vivo assays showing that the inhibition of PDGFRα signaling does not affect the frequency of CSCs, EMT or PD/S-SCC growth. Figure S6. Activation of autocrine FGFR1 signaling in PD/S cells. Figure S7. L-CSC signature identifies advanced and poor-prognosis human lung and head-neck SCCs. Table S1. Histopathological features of distinct primary and orthotopically-derived SCCs (SCC lineages) at different passages. Table S3. List of human skin SCCs samples used in this study. Histopathological features of these samples are described. Supplementary Materials and Methods.