Experimental Evaluation of the Protective Activity of Hepavitol on the Model of Acute Fatty Hepatosis in Rats

The article presents the results of an experiment to determine the protective activity of hepavitol on a model of acute fatty liver degeneration in laboratory rats. Acute fatty hepatosis in animals was caused by a single intragastric administration of an aqueous solution of hydrazine at a dose of 200 mg / kg (40–50 mg / animal), and then the animals were injected with hepavitol for 28 days. The total weight gain of the rats by groups relative to the initial indicators by the end of the experiment was: experimental group “ +” 1.6%, control group “−” 3.7%, intact group “ +” 6.1%. There were also significant changes in the level of LPO products between the experimental and control groups. The level of diene conjugates in the blood of control rats exceeded those of experimental animals in 1.88 times, ketodienes exceeded in 1.75 times, malondialdehyde exceeded by 30.2%, respectively. Experimental animals showed stabilization of hepatoindicator enzymes, total protein and bilirubin almost to the level of healthy animals. The liver histostructure of the rats of the control group was distinguished by extensive areas of granular, fatty degeneration and necrosis of hepatocytes. On the significant part of the liver tissue of the experimental rats, the integrity of hepatocytes and the beam structure of the organ parenchyma were preserved. Thus, from the results obtained in the model experiment, it can be concluded that hepavitol has a pronounced protective activity.