Aptasensors Based on Track-Etched Membranes Coated with a Nanostructured Silver Layer for Influenza A and B Virus Detection

A biosensor based on a polyethylene terephthalate track-etched membrane coated with silver nanoparticles is proposed for the detection of influenza A and B viruses using aptamers for specific sorption of the viruses on the membrane surface as well as for the introduction of a Raman-active or fluorescent label. The analytical signal is recorded using a Raman spectrometer, observing the effects of surface enhancement of the intensity of optical responses from the labels.