(2R,6 ' R,E)-3 '-(1-Aminoethylidene)-7-chloro-4,6-dimethoxy-6 '-methyl-3H-spiro[benzofuran-2,1 '-cyclohexane]-2 ',3,4 '-trione

A novel synthesis approach for griseofulvin derivatives was developed. The presented method is based on a two-stage process that includes preliminary acetylation of griseofulvic acid followed by condensation with ammonium acetate. The advantages of this protocol include readily available starting materials and a simple target product isolation procedure. The structure of the synthesized polycyclic compound was approved by H-1, C-13-NMR spectroscopy, high-resolution mass spectrometry with electrospray ionization (ESI-HRMS), and X-ray diffraction.