Involvement of inorganic phosphate starvation in Pseudomonas aeruginosa bacterial virulence

Pseudomonas aeruginosa is a bacterium causing a wide spectrum of noso-comial and opportunistic respiratory infections. As an element essential for bacterial metabolism, phosphorus is incorporated as an inorganic phosphate and regulated by a two -component PhoB-PhoR system. Recently, it has been shown that as a result of overexpression of virulence factors, including the PhoB transcription factor, P. aeruginosa exhibited increased virulence in phosphate-deficient conditions. Exploration of the relationship between phosphate homeostasis and P. aeruginosa virulence could effectively contribute to the development of new, simple and innovative therapeutic strategies.(c) 2023 SPLF. Published by Elsevier Masson SAS. All rights reserved.