Comparison of the diagnostic values of gd-eob-dtpa and gd-dtpa for hepatocellular carcinoma associated with hepatitis b cirrhosis

Objective: To explore the diagnostic value of Gd-EOB-DTPA MRI for hepatocellular carcinoma (HCC) associated with hepatitis B cirrhosis. Methods: A total of 32 hepatitis B cirrhosis patients with 34 HCC lesions underwent two MRIs (mode 1: T2WI, DWI, T1WI in-phase and opposed-phase and dynamic Gd-DTPA enhancement (native phase, arterial phase, portal-venous phase and delayed phase); mode 2: T2WI, DWI, T1WI in-phase and opposed-phase and dynamic Gd-EOB-DTPA enhancement (native phase, arterial phase, portal-venous phase, delayed phase and hepatobiliary phase). The images were analyzed by two readers with double blind method. The signal characteristic of all lesions, the enhancement modes, and the confidence scores of two readers were recorded. The confidence scores, consistency, areas under the receiver operating characteristic (ROC) curve, sensitivity and positive predictive values (PPV) of two readers in diagnosing the hepatocellular carcinoma were compared between two imaging modes. Results: (1) The confidence scores of two readers in diagnosing the hepatocellular carcinoma under the second imaging mode were higher than those under the first imaging mode, and the differences were statistically significant (P<0.05). The consistency of two readers in diagnosing the hepatocellular carcinoma under the second imaging mode was also increased. (2) The areas under the ROC curve of two readers in diagnosing the hepatocellular carcinoma under the second imaging mode were increased compared with those under the first imaging mode, and the differences were statistically significant (P<0.05). (3) The sensitivities of two readers in diagnosing the hepatocellular carcinoma under the second imaging mode were higher than those under the first imaging mode, and the differences were statistically significant (P<0.05). There were no significant differences in PPV of two readers between two imaging modes (P>0.05). Conclusion: Gd-EOB-DTPA MRI may improve the diagnostic confidences of readers on HCC associated with hepatitis B cirrhosis and thus increase the diagnostic efficacy.