Spiral Shaped Photonic Crystal Fiber-Based Surface Plasmon Resonance Biosensor for Cancer Cell Detection

This work presents the design and simulation of an all-optical sensor for detection of cancer cells. The proposed device is based on the surface plasmon resonance effect on a spiral shaped photonic crystal fiber structure. The finite element method (FEM) based simulations are carried out for the different cancer cells, such as HELA, Basal, Jurkat, and MDA-MB-231, MCF7, and PC12 detection. The sensor has shown the maximum sensitivity of -289 RIU-1 for the refractive index of the detection of breast cancer cell with the resolution of 2.33 x 10-4. The sensor is effective for the refractive index range of 1.36 to 1.401.The structure is based on spiral shaped photonic crystal fiber, and has shown promising linear sensing response to support the practical feasibility of the device. The proposed sensor design is effective in detecting cervical cancer, skin cancer, blood cancer, breast cancer type 1, breast cancer type 2, and adrenal gland cancer.