Two New Anthraquinones from the Marine-Derived Fungus Fusarium sp. J3-2

Two new anthraquinones, (11S)-1,4,6-trihydroxy-7-(1-hydroxyethyl)-3-methoxyanthracene-9,10-dione ( 1 ) and (11S)-1,6-dihydroxy-7-(1-hydroxyethyl)-3-methoxyanthracene-9,10-dione ( 2 ), together with six known compounds, including four naphthoquinones ( 3–6 ), one thiophene derivative ( 7 ), and one cyclohexanedione derivative ( 8 ), were isolated from the mangrove rhizosphere soil-derived fungus Fusarium sp. J3-2. Compound 1 displayed weak to moderate antibacterial activities against five strains of pathogenic bacteria with MIC values ranging from 25 to 50 μg/mL. Compound 3 showed weak cytotoxic activities toward human hepatocellular carcinoma cell lines, SMMC-7721 and SGC-7901, with IC 50 values of 48.87 and 41.23 μg/mL, respectively. Compounds 1–7 exhibited antifouling activities against the larval settlement of the barnacle Balanus amphitrite.