Effects of Microvascular Decompression on Pain Relief and Quality of Life in Late Elderly Patients with Trigeminal Neuralgia

Pharmacotherapy is frequently selected over surgical interventions for late elderly patients with trigeminal neuralgia (TN). However, medication may affect these patients' activities of daily living (ADL). Hence, we investigated the effect of the surgical treatment of TN on ADL in older patients. This study included 11 late elderly patients >75 years old and 26 nonlate elderly patients who underwent microvascular decompression (MVD) for TN at our hospital from June 2017 to August 2021. We evalu-ated pre-and postsurgical ADL using the Barthel Index (BI) score, side effects of antineuralgic drugs, the BNI pain intensity score, and perioperative medication. The BI score of late elderly patients sig-nificantly improved postoperatively, particularly in transfer (pre: 10.5; post: 13.2), mobility (pre: 10; post: 12.7), and feeding (pre: 5.9 points; post: 10 points). Additionally, antineuralgic drugs caused pre-operative disturbances of transfer and mobility. Trends of a longer disease duration and frequent oc-currence of side effects were observed in all patients in the elderly group, compared to only 9 out of 26 patients in the younger group (100% vs. 35%, p = 0.0002). In addition, drowsiness was observed more frequently in the late elderly group (73% vs. 23%, p = 0.0084). However, the change in scores in-dicating improvement after surgery was significantly greater in the late elderly group, although both pre-and postoperative scores were higher in the nonlate elderly group (11.4 +/- 1.9 vs. 6.9 +/- 0.7, p = 0.027). Surgical treatment can improve older patients' ADL because it relieves pain and facilitates dis-continuation of antineuralgic drugs. Consequently, MVD can be positively recommended for older pa-tients with TN if general anesthesia is acceptable.