Copper-catalyzed cross-dehydrogenative coupling of P(O) -H compounds with O-/S-nucleophiles

The copper-catalyzed cross-dehydrogenative coupling of P(O) -H compounds with O-/S-nucleophiles to construct P -O bonds and P -S bonds for the synthesis of phosphinates and phosphinothioates was devel-oped. A broad range of O-and S-nucleophiles are well tolerated in this transformation, affording the tar-get products with good to excellent yields. This protocol is effective and convenient, which not only em-ployed inexpensive copper iodide as the catalyst, but also avoided the use of hazadous and toxic reagents. Through the step-by-step control experiments and competitive experiments, we proposed a plausible re-action mechanism, and further confirmed that the reaction may follow a radical process.(c) 2023 Elsevier B.V. All rights reserved.