A New Ingenane Diterpenoid from Euphorbia jolkinii

A new ingenane diterpenoid, named ingenol-20-laurate (1), and two known analogues (ingenol-20palmitate (2), ingenol-20-pentadecanoate (3)) and an ent-abietane diterpenoid (euphopilolide, 4) were isolated from the whole plants of Euphorbia jolkinii. The structure of compound 1 was elucidated by HRESIMS and 2D NMR methods. The cytotoxicities of compound 1 against SMMC-7721, MDA-MB-231, and SW480 cell lines were 27.22 +/- 0.58, 17.69 +/- 0.29 and 16.19 +/- 0.77 mu M, respectively.