MiR-19b-3p Attenuates Chondrocytes Injury by Inhibiting MAPK/NF-Kappa b Axis via Targeting SOCS1

In this study, miR-19b-3p was downregulated in osteoarthritic cartilage tissues and IL-1 beta-stimulated primary chondrocytes, and miR-19b-3p overexpression reversed the inhibitory effect of IL-1 beta on cell viability, the promotion effects of apoptosis, inflammatory factor secretion and extracellular matrix degradation, whereas the opposite effect was observed with miR-19b-3p inhibitor. Moreover, SOCS1 is a target gene of miR-19b-3p. Furthermore, SOCS1 overexpression enhanced cell injury compared with IL-1 beta alone treatment, whereas knockdown of SOCS1 restored cell damage caused by IL-1 beta. Further studies revealed that miR-19b-3p promoted chondrocyte injury repair by suppressing SOCS1 expression, and we found that was mediated by blocking the MAPK/NF-kappa B axis. Taken together, our findings may provide a new therapeutic strategy for osteoarthritis.