Sodium-Glucose Cotransporter 2 Inhibitors First Strategy Improve Decongestion in Patients with Symptomatic Heart Failure and Reduced Ejection Fraction When Compared to Angiotensin Receptor Neprilysin Inhibitor First Strategy.

Wei-Chieh Lee,Wei-Ting Chang,Chon-Seng Hong,Chia-Te Liao,Po-Sen Huang,Shen-Chung Huang,Chih-Hsien Lin,Chun-Yen Chiang,Zhih-Cherng Chen,Jhih-Yuan Shih

Frontiers in bioscience (Landmark edition)（2023）

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摘要

In patients with symptomatic HFrEF, SGLT2i-first strategy may provide a higher possibility of discontinuing diuretic agents than the ARNI-first strategy. Changes in LV performance, progression of renal function, and clinical outcomes did not differ between the two groups. Early combination (≤14D) provided better LV remodeling.

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关键词

angiotensin receptor neprilysin inhibitor,decongestion,early combination,heart failure with reduced ejection fraction,sacubitril/valsartan,sodium-glucose cotransporter 2 inhibitors

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