Cellular and Humoral Immune Responses to Vaccination for COVID-19 Are Negatively Impacted by Senescent T Cells: A Case Report.

Eliane Aparecida Rosseto-Welter,Silvia Sanches Rodrigues,Amanda Braga de Figueiredo,Carolina Nunes França,Danielle Bruna Leal Oliveira,André Luis Lacerda Bachi,Jônatas Bussador do Amaral,Ricardo Andreotti Siqueira,Laiz Camerão Bento, Ana Paula da Silva,Nydia Strachman Bacal,Carlos Eduardo Dos Santos Ferreira,Cristóvão Luis Pitangueira Mangueira,João Renato Rebello Pinho

Vaccines（2023）

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摘要

CoronaVac elicited an early cellular response, followed by a humoral response, which dropped 90 days after the second dose. The booster with the Pfizer vaccine significantly enhanced these responses. Furthermore, a pro-inflammatory systemic status was found in volunteers who presented senescent T cells, which could putatively impair the immune response to vaccination.

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CoronaVac vaccine,Pfizer vaccine,cell senescence,immunophenotyping,inflammation,neutralizing antibodies

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