Redefining the Incidence and Profile of Fluoropyrimidine-Associated Cardiotoxicity in Cancer Patients: A Systematic Review and Meta-Analysis.

Yajie Lu,Wei Pan,Shizhou Deng,Qiongyi Dou,Xiangxu Wang,Qiang An,Xiaowen Wang,Hongchen Ji,Yue Hei,Yan Chen,Jingyue Yang,Hong-Mei Zhang

Pharmaceuticals (Basel, Switzerland)（2023）

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摘要

Our study provides comprehensive global data on the incidence and profile of FAC. Different cancer types and treatment appear to have varying cardiotoxicities. Combination therapy, high cumulative dose, addition of anthracyclines, and pre-existing heart disease potentially increase the risk of FAC.

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adverse event,cardiotoxicity,fluoropyrimidine,incidence,meta-analysis

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