Genome-Wide Association Study Reveals CLEC7A and PROM1 as Potential Regulators of Paracoccidioides brasiliensis -Induction of Cytokine Production in Peripheral Blood Mononuclear Cells.

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus and the different clinical forms of the disease are associated with the host immune responses. Quantitative trait loci mapping analysis was performed to assess genetic variants associated with mononuclear-cells-derived cytokines induced by on 158 individuals. We identified the rs11053595 SNP, which is present in the gene (encodes the Dectin-1 receptor) and the rs62290169 SNP located in the gene (encodes CD133) associated with the production of IL-1β and IL-22, respectively. Functionally, the blockade of the dectin-1 receptor abolished the IL-1β production in stimulated PBMCs. Moreover, the rs62290169-GG genotype was associated with higher frequency of CD38 Th1 cells in PBMCs cultured with yeasts. Therefore, our research indicates that the and genes are important for the cytokine response induced by and may influence the Paracoccidioidomycosis disease outcome.