Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.

Bing Yan, Xinjie Mao, Shasha Hu, Shimin Wang,Xiaochen Liu,Jing Sun

International immunopharmacology（2023）

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摘要

Our study demonstrated that spermidine rescues intestinal barrier defects in mice with colitis via the AhR-Nrf2 and AhR-STAT3 pathways, providing a potential therapeutic agent for IBD and other conditions associated with dysregulated gut barrier function.

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关键词

AhR,IBD,Intestinal mucosal barrier,Nrf2,STAT3,Spermidine

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