Application of prophylactic or pre-emptive therapy after allogeneic transplantation for high-risk patients with t(8;21) acute myeloid leukemia.

Wenwen Guo,Xin Liu,Mingyang Wang,Jia Liu,Yigeng Cao,Yawei Zheng,Weihua Zhai,Xin Chen,Rongli Zhang,Qiaoling Ma,Donglin Yang,Jialin Wei,Yi He,Aiming Pang,Sizhou Feng,Mingzhe Han,Erlie Jiang

Hematology (Amsterdam, Netherlands)（2023）

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摘要

Patients with pre-MRDpos and post-MRDpos were more likely to have higher rates of relapse and inferior DFS, even after receiving pre-emptive interventions. Prophylactic therapy may be a better option for high-risk t(8;21) AML patients; however, this warrants further investigation.

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关键词

RUNX1-RUNX1T1,acute myeloid leukemia,hematopoietic stem cell transplantation,maintenance therapy,measurable residual disease

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